Publications

2018

Recent Structural Insights into Polycomb Repressive Complex 2 Regulation and Substrate Binding.
Kasinath V*, Poepsel S*, and Nogales E. Biochemistry. 2018.

Structures of human PRC2 with its cofactors AEBP2 and JARID2.
Kasinath V, Faini M, Poepsel S, et al. Science. 2018.

Cryo-EM structures of PRC2 simultaneously engaged with two functionally distinct nucleosomes.
Poepsel S, Kasinath V, and Nogales E. Nat. Struct. Mol. Biol. 2018.

2017

Entropy in molecular recognition by proteins.
Caro JA*, Harpole KW*, Kasinath V*, Lim J*, Granja J, Valentine KG, Sharp KA, and Wand AJ. PNAS.2017.

2014

On the relationship between NMR-derived amide order parameters and backbone entropy changes.
Sharp KA, O'Brien E, Kasinath V, and Wand AJ. Proteins.201583(5) 922-930.

A sharp thermal transition of fast aromatic ring dynamics in ubiquitin..
Kasinath V, Fu Y, Sharp KA and Wand AJ. Angewandte Chemie Intl. Ed.2015, 54(1) 102-107.

Dynamic and thermodynamic response of the Ras protein Cdc42Hs upon association with the effector domain of PAK3.
Moorman VR, Valentine KG, Bedard S, Kasinath V, Dogan J, Love FM and Wand AJ. J. Mol. Biol.2014, 426(21) 3520-3538

Banding of NMR-derived methyl order parameters: Implications for protein dynamics.
Sharp KA, Kasinath V and Wand AJ. Proteins, 2014, 82(9) 2106-2117.

2013

Microscopic insights into the NMR relaxation-based protein conformational entropy meter.
Kasinath V, Sharp KA and Wand AJ. J. Am. Chem. Soc.2013, 135(40), 15092-15100. 

A 13C labeling strategy reveals a range of aromatic side chain motions in calmodulin.
Kasinath V, Valentine KG and Wand AJ. J. Am. Chem. Soc.2013, 135(26), 9560-9563.

2012

Coupled motions in proteins revealed by pressure perturbation
Fu Y, Kasinath V, Moorman VR, Nucci NV, Hilser VJ and Wand AJ. J. Am. Chem. Soc.2012, 134(20), 8543-8550.

Optimized linear prediction for radial sampled multidimensional NMR experiments.
Gledhill JM Jr*, Kasinath V* and Wand AJ. J. Magn. Reson.2011, 212(1), 240-244.

2007

The I-tetraplex building block: rational design and controlled fabrication of robust 1D DNA scaffolds through non-Watson-Crick interactions.
Ghodke HB, Krishnan R, Kasinath V, Kumar GV, Narayana C and Krishnan Y. Angew. Chem. Int. Ed.2007, 46(15), 2646-2649.