Song, J., Gooding, A.R., Hemphill, W.O., Kasinath, V.*, Cech, T.R.*
Structural basis for inactivation of PRC2 by G-quadruplex RNA Science (2023)
*Corresponding Author
Jansson-Fritzberg, L.I., Sousa, C.I., Smallegan, M.J., Song, J.J., Gooding, A.R., Kasinath, V., Rinn, J.L., Cech, T.R.*
DNMT1 inhibition by pUG-fold quadruplex RNA bioRxiv (2022)
* Corresponding Author
Gupta, N.*, Roberts, E.J.*, Pang, S., Xu, C.S., Hess, H.F., Wu, F., Dernburg, A., Jorgens, D., Zwart, P.H.†, and Kasinath, V.†
Deep Learning-based identificatino of sub-nuclear structures in FIB-SEM images. arXiv (2022)
* Contributed equally
† Corrresponding Author
Gargey, A., Yao, L., and Kasinath, V*.
Structural insights into the interaction of Polycomb Repressive Complex 2 with chromatin. Biochemical Society Transactions (2021)
* Corresponding Author
Crosstalk between PRC2 cofactors and H2AK119ub1
Kasinath, V.*, Beck, C., Sauer, P., Poepsel, S., Kosmatka, J., Faini, M., Toso, D., Aebersold, R., and Nogales, E*.
JARID2 and AEBP2 regulate PRC2 in the presence of H2AK119ub1 and other
histone modifications. Science (2021)
* Corresponding Author
Structural Characterization of Polycomb Repressive Complex 2 (PRC2)
Kasinath, V.*, Poepsel, S., and Nogales, E.
Recent Structural Insights into Polycomb Repressive Complex 2 Regulation and Substrate Binding. Biochemistry (2018)
Structure of Human Polycomb Repressive Complex 2 (PRC2) with cofactors JARID2 and AEBP2
Kasinath, V., Faini M, Poepsel S, Reif, D., Feng, XA., Stjepanovic, G., Aebersold, R., and Nogales, E.
Structures of human PRC2 with its cofactors AEBP2 and JARID2. Science (2018)
Poepsel, S., Kasinath, V., and Nogales, E.
Cryo-EM structures of PRC2 simultaneously engaged with two functionally distinct nucleosomes. Nat. Struct. Mol. Biol. (2018)
PRC2 bound to Di-Nucleosome
Universal Entropy Meter for Protein-Ligand Interactions
Caro JA*, Harpole KW*, Kasinath V*, Lim J*, Granja J, Valentine KG, Sharp KA, and Wand AJ.
Entropy in molecular recognition by proteins. PNAS (2017)
*Co-first Authors
Sharp KA, O'Brien E, Kasinath V, and Wand AJ.
On the relationship between NMR-derived amide order parameters and backbone entropy changes. Proteins (2015)
Backbone Conformational Entropy of Proteins
Fluid Nature of the Protein Interior Revealed by High-Pressure NMR
Kasinath V, Fu Y, Sharp KA and Wand AJ.
A sharp thermal transition of fast aromatic ring dynamics in ubiquitin. Angewandte Chemie Intl. Ed. (2015)
Moorman VR, Valentine KG, Bedard S, Kasinath V, Dogan J, Love FM and Wand AJ.
Dynamic and thermodynamic response of the Ras protein Cdc42Hs upon association with the effector domain of PAK3. J. Mol. Biol. (2014)
Dynamics mediated allostery upon effector binding
Sharp K.A., Kasinath V. and Wand A.J.
Banding of NMR-derived methyl order parameters: Implications for protein dynamics. Proteins (2014)
Calibration of Entropy Meter using MD Simulations
Kasinath V., Sharp K.A. and Wand A.J.
Microscopic insights into the NMR relaxation-based protein conformational entropy meter. J. Am. Chem. Soc. (2013)
Kasinath V., Valentine K.G. and Wand A.J.
A 13C labeling strategy reveals a range of aromatic side chain motions in calmodulin. J. Am. Chem. Soc. (2013)
Specific Isotopic labeling of Aromatic Side-chains in Proteins
Fu Y., Kasinath V., Moorman V.R., Nucci N.V., Hilser V.J. and Wand A.J.
Coupled motions in proteins revealed by pressure perturbation. J. Am. Chem. Soc. (2012)
Gledhill J.M. Jr*, Kasinath V.* and Wand A.J.
Optimized linear prediction for radial sampled multidimensional NMR experiments. J. Magn. Reson. (2011)
Ghodke H.B., Krishnan R., Kasinath V., Kumar G.V., Narayana C, and Krishnan Y.
The I-tetraplex building block: rational design and controlled fabrication of robust 1D DNA scaffolds through non-Watson-Crick interactions. Angew. Chem. Int. Ed. (2007)
DNA Nanowires